![]() ![]() Complete eligibility criteria can be reviewed at. All patients need to complete standard radiation therapy before treatment. Other key eligibility criteria, include standard organ function criteria, Lansky/Karnofsky >50, tumor size <5 cm at diagnosis, low or no steroid dose at time of treatment. Frank Lin.Įligible disease are described above. Risk and benefits can be discussed with the principal investigators, Dr. Potential toxicity: The main anticipated toxicity is an inflammatory response at the tumor size, which could cause significant neurological toxicity and possibly cytokine release syndrome.For disease assessment, scans can be done at the referring site.After that the patient will be evaluated outpatient until week 4 and is expected to stay in Houston during this time after this period they can return home. We will administer standard lymphodepleting chemotherapy with cyclophosphamide and fludarabine, which will be given inpatient or outpatient over 3 days, followed by the intravenous CAR T cell infusion and inpatient monitoring for at least 5 days. The Ommaya is used for safe removal of CSF in the case increased intracranial pressure develops and not currently used for cell infusion. Ommaya placement. The patient will need to have an Ommaya in place or have Ommaya placement arranged at referral institution or by our team in Houston before treatment.Will occur at least 4 weeks after completion of standard XRT in newly diagnosed patients. Procurement can be completed before, during or after radiation therapy (XRT). Cell generation and testing takes at least 4-5 weeks. ![]() Blood can be collected remotely at the referral institution if preferred and shipped to Texas Children’s Hospital. White blood cells are collected by a blood draw of 60 ml. Procurement. Procurement consent can be obtained remotely. ![]()
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